DSynNALAB

01 — Services

Services

We give research groups the infrastructure and expertise to construct large, complex DNA for synthetic genomics — from the first conversation to a verified construct.

Large & complex DNA assembly

Construction of large, multi-part DNA constructs that are difficult or impossible to source commercially — from kilobase pathways and genetic circuits to whole genomic loci.

We employ in vitro and in vivo methods for scalable DNA assembly in the range of 5 to 200 kbp.

TAR assembly service module

Yeast-based assembly of synthetic DNA segments.

Yeast-based assembly of synthetic DNA segments. Synthetic DNA segments are divided into several overlapping fragments with unique homology regions, including terminal homology to an acceptor plasmid. The fragments and acceptor plasmid are introduced into yeast, where homologous recombination assembles them into a complete DNA segment within the plasmid.

Full plasmid sequencing service module

Pooled plasmid library preparation and verification.

Pooled plasmid library preparation and verification. This workflow enables the recovery, expansion, and sequence verification of pooled plasmid libraries. Plasmids are first rescued from yeast colonies through DNA extraction and then introduced into E. coli by high-efficiency transformation. Individual clones are randomly picked, arrayed, and replicated before being pooled for transposome-based library preparation. The resulting libraries are then sequenced to verify and index the assembled DNA blocks.

Sequence diversification

Generation of variant libraries and diversified constructs for screening, directed evolution, and design-build-test cycles.

Diversification for biological insight.

Diversification of large sequencs. Bottom-up construction of a diverse set of DNA sequences combined with machine learning (ML) and artificial intelligence (AI) promises biological insights.

Method & technology development

Custom in vitro and in vivo cloning workflows, co-developed with you and supported by lab (semi-)automation if required by your project.

See also Research & collaboration.

Community & outreach

Training, knowledge sharing, and public engagement to grow synthetic genomics capacity across the center and beyond.

We are part of the Global Biofoundry Alliance since 2024.

Our User Rules and Prices

Please find our Individual User Agreement, Service and Price List and User Rules and Regulations in the following document.

How to order

Depending on what you need we work as a fee-for-service provider or a collaborative partner. Most projects start with a short conversation about what you need and what is feasible.

  1. Get in touch
    Email us a brief description of your construct or goal — sequence(s), size, intended host, and timeline. For new users, please also read and sign our Individual User Agreement above.
  2. Scoping & feasibility
    We discuss the design, assess feasibility, and agree on an approach, deliverables, and rough turnaround.
  3. Build & verify
    We assemble and quality-control your construct, keeping you updated through the design-build-test cycle.
  4. Delivery
    You receive verified material plus documentation; we follow up on any iteration you need.

Ready to start? Get in touch.